Clinical Chemistry
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Clinical Chemistry 18: 250-257, 1972;
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Clinical Chemistry, Vol 18, 250-257, Copyright © 1972 by the American Association for Clinical Chemistry

Computerized Preparation of Two-Way Analysis of Variance Control Charts for Clinical Chemistry

J. H. Riddick Jr. 1, Roger Flora 1, and Quentin L. Van Meter 1

1 Division of Clinical Pathology (J. H. R. and Q. L. V. M.) and the Department of Biometry (R. F.), Medical College of Virginia, Virginia Commonwealth University, Richmond, Va. 23219.

A system of quality-control data analysis by computer is described, in which two-way analysis of variance is used for partitioning sources of laboratory error into day-to-day, within-day, betweenpools and additivity variation. The partition for additivity is described in detail as to its advantages and applications. In addition, control charts based on two-way analysis of variance computations are prepared each month by computer. This computer program is designed to operate with the IBM 1800 or 1130 computers or any computer with a Fortran IV compiler. Examples are presented of use of the control charts and of tables of analysis of variance.


Key Words: trouble-detection • laboratory error partition • test for additivity in analysis of variance • AutoAnalyzer • statistical methods and quality control

Submitted on July 14, 1971
Accepted on December 2, 1971






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Copyright © 1972 by the American Association for Clinical Chemistry.