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Clinical Chemistry 18: 280-284, 1972;
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Clinical Chemistry, Vol 18, 280-284, Copyright © 1972 by the American Association for Clinical Chemistry

Implication of Creatinine and Gut Flora in the Uremic Syndrome: Induction of "Creatininase" in Colon Contents of the Rat by Dietary Creatinine

James D. Jones 1 and Philip C. Burnett 1

1 Mayo Clinic and Mayo Foundation, Rochester, Minn. 55901.

"Creatininase" activity was induced in the colon flora of rats by feeding creatinine. Sarcosine and methylamine were tentatively identified as the major products of the enzymic action. A third (unidentified) compound was observed. These compounds and methylguanidine were labeled in the urine of rats given 14CH3-creatinine orally. The results suggest that creatinine should not be considered biologically inert in animals, especially in those with decreased renal function.


Key Words: 14CH3-creatinine • methylguanidine • sarcosine • methylamine • uremic toxins • ion-exchange chromatography • urea metabolism in hepatic coma

Submitted on October 11, 1971
Accepted on December 13, 1971




The following articles in journals at HighWire Press have cited this article:


Home page
 Physiol. Rev.Home page
M. Wyss and R. Kaddurah-Daouk
Creatine and Creatinine Metabolism
Physiol Rev, July 1, 2000; 80(3): 1107 - 1213.
[Abstract] [Full Text] [PDF]


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Copyright © 1972 by the American Association for Clinical Chemistry.