Clinical Chemistry
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Clinical Chemistry 18: 355-357, 1972;
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Clinical Chemistry, Vol 18, 355-357, Copyright © 1972 by the American Association for Clinical Chemistry

Semiautomated Method for Measurement of Guanidinosuccinic Acid in Serum

P. P. Kamoun 1, J. M. Pleau 1, and N. K. Man 1

1 Clinique Néphrologique, Hôpital Necker, 161 Rue de Sèvres, Paris 15, France.

A semiautomated method for analysis of guanidinosuccinic acid is described. To separate it from interfering guanidino compounds, it is absorbed on and eluted from an anion-exchange column. Colorimetry of the eluate was by Barrit’s [J. Pathol. Bacteriol. 42, 441 (1936)] modification of the Voges-Proskauer reaction.


Key Words: hemodialysis • renal insufficiency • AutoAnalyzer • Voges-Proskauer reaction • guanidino compounds • anion-exchange chromatography

Submitted on November 29, 1971
Accepted on January 27, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.