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Clinical Chemistry, Vol 18, 358-362, Copyright © 1972 by the American Association for Clinical Chemistry
1 Clinical Chemistry Laboratory, Presbyterian
Hospital, 630 West 168th St., New York, N. Y. 10032.
Serum 
-glutamyl transpeptidase (GGT), leucine
aminopeptidase, alkaline phosphatase, alanine
aminotransferase, and aspartate aminotransferase
activities were assayed in controls and in patients
with liver, pancreatic, or bone disease. GGT
activity was above normal in all forms of liver
disease studied (viral hepatitis, cirrhosis, cholecystitis, metastatic carcinoma to liver, pancreatic
carcinoma, liver granuloma, and acute pancreatitis). GGT more sensitively indicated hepatic
disease than did alkaline phosphatase, much more
so than did leucine aminopeptidase. GGT was
disproportionately more active in relation to the
transaminases in cases of intraor extrahepatic
biliary obstruction; the reverse was true in cases of
viral hepatitis. GGT activity was normal in children,
adolescents, and pregnant women, and in cases
of bone disease and renal failure. Kinetic measurement of GGT activity offers a simple, sensitive,
and direct means for distinguishing whether bone
or liver is the source of increased serum alkaline
phosphatase activity. Activity was highest in
obstructive liver disease.
Submitted on December 17, 1971
Accepted on January 31, 1972
The following articles in journals at HighWire Press have cited this article:
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  M. G. Sturgill and G. H. Lambert Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function Clin. Chem., August 1, 1997; 43(8): 1512 - 1526. [Abstract] [Full Text] [PDF]
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 J. Bhatia and D. K. Rassin Photosensitized Oxidation of Tryptophan and Hepatic Dysfunction in Neonatal Gerbils JPEN J Parenter Enteral Nutr, July 1, 1985; 9(4): 491 - 495. [Abstract] [PDF]
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 J. Jimenez-Alonso, J. M. Rivera, R. Munoz, F. Perez-Jimenez, P. Benito, J. Antonio, and Jimenez-Pereperez Serum {gamma}-Glutamyltransferase (GGT) and Thyroid Disease Arch Intern Med, May 1, 1983; 143(5): 1070 - 1072. [Abstract] [PDF]
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F. Azizi {gamma}-Glutamyl Transpeptidase Levels in Thyroid Disease Arch Intern Med, January 1, 1982; 142(1): 79 - 81. [Abstract] [PDF]
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 M. S. Platt, J. L. Potter, C. R. Boeckman, and C. Jaberg Elevated GGTP/SGOT Ratio: An Early Indicator of Infantile Obstructive Cholangiopathy Arch Pediatr Adolesc Med, September 1, 1981; 135(9): 834 - 836. [Abstract] [PDF]
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 J. S. Loder Sensitivity of Liver Function Tests JAMA, May 10, 1976; 235(19): 2080 - 2080. [Abstract] [PDF]
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