Clinical Chemistry
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Clinical Chemistry 18: 363-365, 1972;
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Clinical Chemistry, Vol 18, 363-365, Copyright © 1972 by the American Association for Clinical Chemistry

Simple Fluorometric Method for Estimating Practolol [1-(4-Aminophenoxy)-3-isopropylaminopropan-2-ol] in Blood and Urine

Gunter Bodem 1 and Charles A. Chidsey 1

1 Departments of Medicine and Pharmacology, University of Colorado Medical Center, Denver, Colo. 80220.

A fluorometric method has been devised for determining practolol [1-(4-aminophenoxy)-3-isopropylaminopropan-2-ol], a new beta-adrenergic receptor antagonist, in blood and urine. The conjugate of deacetylated practolol with nitrosonaphthol is highly fluorescent in weak acid. The excitation wavelength used is 460 nm, the emission wavelength 550 nm.


Key Words: beta-adrenergic antagonist • nitrosonaphthol • cardiac adrenergic receptor blockade • paper chromatography

Submitted on November 3, 1971
Accepted on February 2, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.