Clinical Chemistry
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Clinical Chemistry 18: 422-426, 1972;
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Clinical Chemistry, Vol 18, 422-426, Copyright © 1972 by the American Association for Clinical Chemistry

Clinical Evaluation of a Modified "Oxford T4-by-Column" Method for Serum Thyroxine

Marcia Lee 1, Norbert W. Tietz 1, and Charles J. Martinez 1

1 Mount Sinai Hospital Medical Center and The University of Health Sciences/The Chicago Medical School, California Ave. at 15th St., Chicago, Ill. 60608.

Three commercially available kits for determining serum thyroxine (T4) by column were evaluated. Results with all were less than satisfactory, but a series of changes in the Oxford method resulted in increased reproducibility, substantially improved recovery, and extended linearity of the standard curve. Results compared well with the thyrometabolic status of patients and normal individuals. The 95% confidence limits for 219 "normal" hospital employees were 2.9-6.2 µg/100 ml. The suggested normal range for 241 clinically euthyroid patients is 2.5-6.0 µg/100 ml. The coefficient of correlation between results of the proposed method and of the PBI method was 0.30; for the T4 by the Murphy—Pattee method it was 0.75.


Key Words: three commercial kits for thyroxine evaluated • normal range • PBI method • Murphy—Pattee method

Accepted on February 18, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.