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Clinical Chemistry 18: 471-472, 1972;
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Clinical Chemistry, Vol 18, 471-472, Copyright © 1972 by the American Association for Clinical Chemistry

Hydrochlorothiazide Interference with Urinary Estriol Determination

Arthur F. Rosenthal 1 and Marie R. Tomson 1

1 Department of Laboratories, The Long Island Jewish Medical Center, New Hyde Park, N. Y. 11040.

The commonly used diuretic, hydrochlorothiazide, interferes with the determination of urinary estriol, by destroying the latter during acid hydrolysis. Urine specimens from pregnant patients taking this diuretic may therefore show falsely low estriol values.


Key Words: acid and enzymatic hydrolysis of estriol conjugates • pregnancy urine • chlorothiazide • acetazolamide • low urinary estriol excretion • placental function assessment

Submitted on December 27, 1971
Accepted on January 17, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.