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Clinical Chemistry 18: 519-522, 1972;
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Clinical Chemistry, Vol 18, 519-522, Copyright © 1972 by the American Association for Clinical Chemistry

Nucleic Acid Concentrations in Normal Human Plasma

Richard C. Kamm 1 and Albert G. Smith 1

1 Department of Pathology, University of Tennessee Medical Units, Memphis, Tenn. 38103.

Department of Pathology, Louisiana State University Medical Center, P. O. Box 3932, Shreveport, La. 71130; address reprint requests to this address.

Utilizing a simple, rapid, and inexpensive modification of a fluorometric method, we determined the normal concentrations of nucleic acids (DNA and RNA) in human blood plasma of healthy individuals. DNA concentrations (13.9 ± 3.7 mg/ liter) were in excellent agreement with those reported by other methods. However, the RNA concentrations (144 ± 22 mg/liter) we found were higher than previously reported values, possibly because ribonuclease activity is more inhibited in this fluorometric method.


Key Words: fluorometric method • DNA and RNA • ribonuclease inhibition • normal values

Submitted on August 30, 1971
Accepted on March 28, 1972




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