Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 18: 528-533, 1972;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Katz, F. H.
Right arrow Articles by Smith, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Katz, F. H.
Right arrow Articles by Smith, J. A.

Clinical Chemistry, Vol 18, 528-533, Copyright © 1972 by the American Association for Clinical Chemistry

Radioimmunoassay of Angiotensin I: Comparison of Two Renin Activity Methods and Use for Other Measurements of the Renin System

Fred H. Katz 1 and Judith A. Smith 1

1 Department of Medicine, University of Colorado Medical Center, and Veterans Administration Hospital, Denver, Colo. 80220.

Standard curves for radioimmunoassay of angiotensin I vary with the amount of plasma or plasma extract present in the assay samples. Therefore results of all such analyses must be compared with standards processed precisely like the unknowns. Results of renin activity, assayed directly in plasma or plasma extracts, corresponded well, demonstrating the comparability of the two types of methods. We describe simplifications in measuring activity, substrate, and concentration of renin, and emphasize use of the optimum pH for determining action of the enzyme. In addition, we present evidence for the presence of angiotensin I in the circulation, especially after renin secretion is stimulated.


Key Words: normal values • plasma renin activity • renal hypertension • plasma renin substrate, activity, and concentration measurements • factors affecting antibody binding • angiotensin I in plasma

Submitted on February 28, 1972
Accepted on April 4, 1972




The following articles in journals at HighWire Press have cited this article:


Home page
 Arch Intern MedHome page
R. H. Noth, M. N. Lassman, S. Y. Tan, A. Fernandez-Cruz Jr, and P. J. Mulrow
Age and the Renin-Aldosterone System
Arch Intern Med, October 1, 1977; 137(10): 1414 - 1417.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1972 by the American Association for Clinical Chemistry.