Clinical Chemistry
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Clinical Chemistry 18: 539-543, 1972;
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Clinical Chemistry, Vol 18, 539-543, Copyright © 1972 by the American Association for Clinical Chemistry

Factors Affecting the Radioimmunoassay of Digoxin

Eugene Cerceo 1 and Cipriano A. Elloso 1

1 Department of Chemistry, Clinical Laboratories, Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, Pa. 19107.

We ascertained which factors critically affect the radioimmunoassay of digoxin. These include: products of hemolysis in blood plasma, excessive amounts of bilirubin in the plasma of jaundiced patients, the age of the tritiated digoxin, the presence of gamma-emitting radioisotopes in the plasma from diagnostic tests, the binding tendency of plasma proteins for digoxin, chemiluminescence associated with the serum (or plasma) of uremic patients, and excessive delay between sample collection and assay of unfrozen samples.


Key Words: liquid scintillation counting • color quenching • tritiated digoxin • quench correction • free circulating digoxin • binding tendency of plasma proteins

Submitted on February 12, 1972
Accepted on April 12, 1972




The following articles in journals at HighWire Press have cited this article:


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 JAMAHome page
R. H. Goldman
The Use of Serum Digoxin Levels in Clinical Practice
JAMA, July 15, 1974; 229(3): 331 - 332.
[Abstract] [PDF]


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Copyright © 1972 by the American Association for Clinical Chemistry.