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Clinical Chemistry 18: 554-562, 1972;
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Clinical Chemistry, Vol 18, 554-562, Copyright © 1972 by the American Association for Clinical Chemistry

Direct-Contact (Membraneless) Hemoperfusion through Oils

M A. Evenson 1 and D. de Vos 1

1 Department of Medicine, University of Wisconsin, 1300 University Ave., Madison, Wis. 53706.

Oil-hemoperfusion is a highly promising procedure, as indicated by in vitro feasibility studies with human blood and in vivo experiments with rhesus monkeys. Direct liquid—liquid extraction is used to remove toxic or unwanted substances from whole blood. By choosing the proper oil or modification of an oleaginous liquid, cholesterol, total bilirubin, and lipid-soluble drugs such as glutethimide can be selectively removed or adjusted to the desired concentration with a single liquid—liquid extraction. Damage or loss of cellular components such as erythrocytes, leukocytes, and platelets is immeasurably small or nonexistent. Undesirable extraction of other vital biological substances and (or) back extraction of substances from the oil into the blood is so small that side effects or aftereffects of in vivo oil-hemoperfusion studies were considerably less than anticipated.


Key Words: continuous-flow extraction of blood • toxicity of oils in contact with blood • cellular damage, blood • glutethimide extraction • cholesterol and bilirubin extraction • drug abuse • removal of lipid-soluble substances from blood • blood oxygenation

Submitted on March 23, 1972
Accepted on April 8, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.