Clinical Chemistry
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Clinical Chemistry 18: 565-566, 1972;
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Clinical Chemistry, Vol 18, 565-566, Copyright © 1972 by the American Association for Clinical Chemistry

Detection of Patients with Low Serum Cholinesterase Activity: Inadequacy of "Acholest" Method

Albert A. Dietz 1, Herbert Rubinstein 1, and Tina Lubrano 1

1 Research and Medical Services, Veterans Administration Hospital, Hines, Ill. 60141; and the Departments of Biochemistry and Medicine, Loyola University Stritch School of Medicine, Maywood, Ill. 60153.

The "Acholest" test-paper method for estimating serum cholinesterase activity has been suggested as a preoperative screening test for patients potentially liable to prolonged apnea after use of succinylcholine. The method was tested on selected sera from normal persons and from patients with various hereditary variants of serum cholinesterase and results were compared to those obtained with a standard quantitative assay. The Acholest method failed to detect 12 of 20 cases at high risk of prolonged apnea after succinylcholine. It cannot therefore be considered as a suitable screening procedure.


Key Words: apnea after succinylcholine • screening method • diagnostic kits

Submitted on January 31, 1972
Accepted on March 1, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.