Clinical Chemistry
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Clinical Chemistry 18: 666-667, 1972;
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Clinical Chemistry, Vol 18, 666-667, Copyright © 1972 by the American Association for Clinical Chemistry

Rapid Estimation of Fibrinogen in Fibrinolytic and Nonfibrinolytic States

Arthur A. Rosenberg 1 and Richard A. Peabody 1

1 Laboratory Service and Surgical Research Laboratory, Research Service, of the Veterans Administration Hospital, 113 Holland Ave., Albany, N. Y. 12208.

Anticoagulated whole blood is serially diluted in a fibrinolytic inhibitor, then clotted with thrombin after adding calcium chloride. The clotting end point, visualized by addition of saline, is related to the concentration of clottable protein present. Protection of the forming clot against lysis is afforded by the inhibitor, by calcium chloride, and by the brief incubation at room temperature, and enables blood fibrinogen concentration to be readily discernible, even if it is less than 25 mg/100 ml. Fibrinogen in the blood is quickly estimated irrespective of the patient’s clinical status.


Key Words: hemorrhage control • thrombosis • embolism • fibrinolysis • normal range • egr-aminocaproic acid as lysis inhibitor

Submitted on April 5, 1972
Accepted on April 17, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.