Clinical Chemistry
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Clinical Chemistry 18: 984-986, 1972;
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Clinical Chemistry, Vol 18, 984-986, Copyright © 1972 by the American Association for Clinical Chemistry

Determination of Phenylbutazone in Plasma

Eberhard Jähnchen 1 and Gerhard Levy 1

1 Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, N. Y. 14214.

The permanganate oxidation method for the spectrophotometric determination of phenylbutazone has been modified and optimized to permit precise assays of phenylbutazone in small plasma samples. The assay is not affected by the presence of p-hydroxyphenylbutazone, the major metabolite of phenylbutazone. Weak bases are removed in the initial extraction procedure, and weak acids such as phenobarbital, warfarin, diphenylhydantoin, salicylic acid, and sulfadiazine do not interfere in the assay.

Submitted on May 29, 1972
Accepted on July 4, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.