Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 19: 31-35, 1973;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ten Cate, J. W.
Right arrow Articles by Glasius, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ten Cate, J. W.
Right arrow Articles by Glasius, E.

Clinical Chemistry, Vol 19, 31-35, Copyright © 1973 by the American Association for Clinical Chemistry

Biological Activity of a Semisynthetic Flavonoid, O-(beta-Hydroxyethyl)rutoside: Light-Scattering and Metabolic Studies of Human Red Cells and Platelets

J. W. ten Cate 1, N. J. van Haeringen 1, J. Gerritsen 1, and E. Glasius 1

1 From the Department of Haematology of the University Hospital (J. W. t.C. and J. G.) and the Netherlands Ophthalmic Research Institute (NORI) (N. J. v. H. and E. G.), "Wilhelmina Gasthuis," Eerste Helmersstraat 104, Amsterdam-Oud West, The Netherlands

The effect of O-(beta-hydroxyethyl)-rutoside (HR) on human erythrocyte and platelet functions is reported. Only high concentrations of the compound distinctly inhibited red cell and platelet aggregation induced by ADP and epinephrine. Lower concentrations of HR inhibit [14C8]adenosine incorporation into red cells as well as into platelets. Inhibition occurs at both 0°C and 37°C, presumably because diffusion of [14C8]adenosine is hindered. Phosphorylation of [14C8] adenosine by the platelets is not inhibited by HR. The inhibition of red cell aggregation is reversed by washing the cells with plasma. Collectively, these findings indicate an effect of the compound at the site of the membrane, independent of cellular metabolism


Key Words: rouleaux formation • poor venous circulation • binding sites on red cell membranes aggregation of red cells and of platelets • incorporation of radiolabeled adenosine • phosphorylation

Submitted on July 5, 1972




The following articles in journals at HighWire Press have cited this article:


Home page
 ANGIOLOGYHome page
V. Petruzzellis, T. Troccoli, C. Candiani, R. Guarisco, M. Lospalluti, G. Belcaro, and M. Dugall
Oxerutins (Venoruton(R)): Efficacy in Chronic Venous Insufficiency: A Double-Blind, Randomized, Controlled Study
Angiology, May 1, 2002; 53(3): 257 - 263.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
E. Bouskela and K. A. Donyo
Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch
Angiology, May 1, 1997; 48(5): 391 - 399.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 by the American Association for Clinical Chemistry.