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Clinical Chemistry 19: 31-35, 1973;
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Clinical Chemistry, Vol 19, 31-35, Copyright © 1973 by the American Association for Clinical Chemistry

Biological Activity of a Semisynthetic Flavonoid, O-(beta-Hydroxyethyl)rutoside: Light-Scattering and Metabolic Studies of Human Red Cells and Platelets

J. W. ten Cate 1, N. J. van Haeringen 1, J. Gerritsen 1, and E. Glasius 1

1 From the Department of Haematology of the University Hospital (J. W. t.C. and J. G.) and the Netherlands Ophthalmic Research Institute (NORI) (N. J. v. H. and E. G.), "Wilhelmina Gasthuis," Eerste Helmersstraat 104, Amsterdam-Oud West, The Netherlands

The effect of O-(beta-hydroxyethyl)-rutoside (HR) on human erythrocyte and platelet functions is reported. Only high concentrations of the compound distinctly inhibited red cell and platelet aggregation induced by ADP and epinephrine. Lower concentrations of HR inhibit [14C8]adenosine incorporation into red cells as well as into platelets. Inhibition occurs at both 0°C and 37°C, presumably because diffusion of [14C8]adenosine is hindered. Phosphorylation of [14C8] adenosine by the platelets is not inhibited by HR. The inhibition of red cell aggregation is reversed by washing the cells with plasma. Collectively, these findings indicate an effect of the compound at the site of the membrane, independent of cellular metabolism


Key Words: rouleaux formation • poor venous circulation • binding sites on red cell membranes aggregation of red cells and of platelets • incorporation of radiolabeled adenosine • phosphorylation

Submitted on July 5, 1972




The following articles in journals at HighWire Press have cited this article:


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V. Petruzzellis, T. Troccoli, C. Candiani, R. Guarisco, M. Lospalluti, G. Belcaro, and M. Dugall
Oxerutins (Venoruton(R)): Efficacy in Chronic Venous Insufficiency: A Double-Blind, Randomized, Controlled Study
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[Abstract] [PDF]

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E. Bouskela and K. A. Donyo
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[Abstract] [PDF]


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Copyright © 1973 by the American Association for Clinical Chemistry.