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Clinical Chemistry 19: 58-61, 1973;
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Clinical Chemistry, Vol 19, 58-61, Copyright © 1973 by the American Association for Clinical Chemistry

Trimethylsilylation of Malonate Ester Enols

O. A. Mamer 1 and S. S. Tjoa 1

1 From the Mass Spectrometry Unit, Royal Victoria Hospital, Department of Experimental Medicine, McGill University, Montreal 112, Quebec, Canada

Malonic acid silylates readily to yield the expected bis-trimethylsilyl (TMS) ester; this ester reacts further in the silylating mixture to yield a tris-TMS derivative, apparently through enolization of one of the ester groups. Methylmalonic and hydroxymalonic acids behave similarly. The methyl and ethyl esters of malonic acid also silylate once with some facility. Mass spectra of these derivatives are presented


Key Words: measurement of methylmalonic acid in biological fluids • trimethylsilylation of organic acids • mass spectra of silylated acids

Accepted on October 20, 1972






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Copyright © 1973 by the American Association for Clinical Chemistry.