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Clinical Chemistry 19: 62-66, 1973;
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Clinical Chemistry, Vol 19, 62-66, Copyright © 1973 by the American Association for Clinical Chemistry

Cooperative Survey of "SMA" Analyzers in Wisconsin—A Method of Improving Interlaboratory Performance

Ronald H. Laessig 1, Thomas H. Schwartz 1, and Toni A. Paskey 1

1 From the State Laboratory of Hygiene, University of Wisconsin Medical Center, Madison, Wis. 53706 (RHL and TAP); and the Multiphasic Health Screening Program, Department of Health and Social Services, Bureau of Preventable Disease, Madison, Wis. 53702

A state-wide cooperative quality-control program for automated multichannel analytical systems is described. The survey benefits participating laboratories by providing, through regular comparison, a means of improving interlaboratory precision. A common lot of reference material used for a large group of similar multichannel analyzers is shown to significantly improve their precision. The study delineates components of interlaboratory variation resulting from the inconsistency of the reference materials and from the inherent precision of the analyzers. Errors in the assay values of commercial controls and reference sera, as well as problems of homogeneity in these products, are documented. These errors make some form of regular interlaboratory comparison an essential element of a total quality-control program


Key Words: State-wide quality-control program • accuracy and precision • reference materials • multiphasic health screening • calibration and standardization

Submitted on June 28, 1972
Accepted on October 25, 1972






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Copyright © 1973 by the American Association for Clinical Chemistry.