Clinical Chemistry
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Clinical Chemistry 19: 76-80, 1973;
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Clinical Chemistry, Vol 19, 76-80, Copyright © 1973 by the American Association for Clinical Chemistry

Determination of Lead in Blood and Urine by Anodic Stripping Voltammetry

Bernard Searle 1, Wing Chan 1, and Bernard Davidow 1

1 From The New York City Department of Health, 455 First Ave., New York, N. Y. 10016

An anodic stripping procedure for determining lead in blood and urine was evaluated, and methods of calibration were developed. The technique requires as little as 50 µl of blood or 0.5 ml of urine. Comparisons were made between results obtained by anodic stripping voltammetry, for finger-puncture blood, and by atomic absorption spectrophotometry, for venous blood from 200 children. The two methods were also compared with respect to lead in urines from patients hospitalized for suspected lead poisoning and in urines from normal healthy volunteers. Major advantages of the anodic stripping method are its increased sensitivity and lower cost as compared to many current methods for detecting and measuring lead


Key Words: environmental hazards • lead poisoning • atomic absorption spectrophotometry compared • Pb in capillary and venous blood • ultramicromethods for trace metals

Submitted on August 16, 1972
Accepted on October 30, 1972




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Copyright © 1973 by the American Association for Clinical Chemistry.