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Clinical Chemistry 19: 99-102, 1973;
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Clinical Chemistry, Vol 19, 99-102, Copyright © 1973 by the American Association for Clinical Chemistry

Electrophoresis, Specific Protein Assays, or Both in Measurement of Plasma Proteins?

Carl Bertil Laurell 1

1 From the Department of Clinical Chemistry, University of Lund, Malmö General Hospital, Malmö, Sweden

Cumulative knowledge of the protein composition of plasma and newer techniques for specific analysis of proteins have made obsolete most flocculation tests, the albumin:globulin ratio, scanning diagrams, and most determinations of electrophoretic fractions. More clinically relevant information about the serum protein composition is obtained by critical visual evaluation of the protein bands obtained after electrophoretic separation of plasma or serum in nonadsorptive supporting media, if supplementary specific analysis is made of a small number of proteins such as albumin, orosomucoid, haptoglobins, ceruloplasmin, and the immunoglobulins of the three predominant classes


Key Words: Clinical utility of elaborate protein separations • interpretation of electrophoretic patterns • needed research by clinical chemists • immunochemical techniques • diagnostic aids

Submitted on October 2, 1972







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Copyright © 1973 by the American Association for Clinical Chemistry.