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Clinical Chemistry 19: 1101-1105, 1973;
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Clinical Chemistry, Vol 19, 1101-1105, Copyright © 1973 by the American Association for Clinical Chemistry

Radioassay of Serum Folate

Ralph T. Dunn 1 and Lowell B. Foster 1

1 Patterson Coleman Laboratories, 4600 N. Habana, Tampa, Fla. 33614.

We describe a radioassay procedure for serum folate, in which commercially available crystalline beta-lactoglobulin is used as the folate-binding agent. The folate binders present in serum are eliminated by heating serum in a boiling water bath for 15 min to denature the proteins. Radioassayable serum folate is shown to be stable under these conditions, and the results for folate compare well with those obtained by a microbiological assay.


Key Words: Competitive binding assay for folate • isotope dilution assay for folate • beta-lactoglobulin binding of folate • comparison with microbioassay • stability of folate • elimination of folate binding by serum proteins • normal values

Submitted on May 18, 1973
Accepted on July 5, 1973




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