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Clinical Chemistry 19: 1142-1147, 1973;
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Clinical Chemistry, Vol 19, 1142-1147, Copyright © 1973 by the American Association for Clinical Chemistry

Isoenzymes of Liver Alkaline Phosphatase in Serum of Patients with Hepatobiliary Disorders

Douglas P. Rhone 1, Florence M. White 1, and Helene Gidaspow 1

1 Section of Clinical Chemistry, Department of Pathology, Illinois Masonic Medical Center, 836 W. Wellington Ave., Chicago, Ill. 60657.

The isoenzymes of alkaline phosphatase (ALP; EC 3.1.3.1) present in the [unknown]sera of 116 patients with hepatobiliary disease were studied by electrophoresis on cellulose acetate. Individual liver isoenzyme bands were identified and quantitated by densitometric scanning. The occurrence and magnitude of increase of the isoenzyme bands of liver ALP (agr2 alone or agr1 and agr2) are related to diagnosis. Of the cases studied, 30% showed only the agr2 band of liver ALP. A couplet of liver isoenzyme bands (agr1 and agr2) was seen in 70% of the cases studied. The isolated agr2 band occurred in 26 of 36 patients with viral hepatitis and in two patients with hepatic infarction. Most patients with other liver diseases showed the agr1 and agr2 couplet. The serum pattern of liver ALP is related to total ALP, age, ABO blood group, and serum bilirubin concentration. The agr1 band is markedly increased in patients with granulomatous hepatitis and carcinoma metastatic to the liver. The findings are related to previous work, and their implications are discussed.


Key Words: diagnostic aid • electrophoresis on cellulose acetate • isoenzymes as indicator of hepatobiliary disease • cervical carcinoma • relation to ABO blood group

Submitted on April 6, 1973
Accepted on July 23, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.