Clinical Chemistry
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Clinical Chemistry 19: 1158-1161, 1973;
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Clinical Chemistry, Vol 19, 1158-1161, Copyright © 1973 by the American Association for Clinical Chemistry

Comparison of Glutethimide Concentration in the Serum and Cerebrospinal Fluid of Humans in Drug Overdose

Martin Gold 1, Ernest Tassoni 1, and Michael Etzl 1

1 Nazareth Hospital, 2601 Holme Ave., Philadelphia, Pa. 19152.

Glutethimide concentrations were measured gas chromatographically in the serum and cerebrospinal fluid (CSF) of patients in coma caused by overdose of this drug. Piperidione was used as an internal standard. In the first serum samples collected from each patient, the glutethimide concentration ranged from 0.9 to 3.1 mg/dl. No patient had a CSF glutethimide concentration of more than 0.8 mg/dl. If one excludes patients who regained consciousness in less than 7 h, the seven remaining cases may be described by the following equation: y = 16.06 x1.06 where y = duration of coma (in h) and x = maximum serum glutethimide concentration (in mg/dl). The correlation coefficient for this equation was 0.911.


Key Words: gas chromatography

Submitted on April 30, 1973
Accepted on August 6, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.