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Clinical Chemistry 19: 1184-1186, 1973;
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Clinical Chemistry, Vol 19, 1184-1186, Copyright © 1973 by the American Association for Clinical Chemistry

Comparison of Four Methods for Measuring Uric Acid: Copper-Chelate, Phosphotungstate, Manual Uricase, and Automated Kinetic Uricase

Gifford Lum 1 and S. Raymond Gambino 1

1 Clinical Chemistry Laboratory, Presbyterian Hospital, 630 West 168th St., New York, N. Y. 10032.

Glutathione, ascorbic acid and many commonly used antibiotics falsely elevate uric acid concentrations when measured with the Du Pont "aca," in which the copper-chelate method is used. L-Dopa interferes with both the copper-chelate method and the Technicon "SMA 12/60" phosphotungstate method. A new kinetic uricase method has been developed for use on the Du Pont aca. This kinetic uricase method has a coefficient of variation of 2.40% and gives values that are essentially identical to those obtained by a manual end-point uricase method.

Submitted on June 29, 1973
Accepted on August 17, 1973




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Clin. Chem., September 1, 2008; 54(9): 1473 - 1480.
[Abstract] [Full Text] [PDF]


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Copyright © 1973 by the American Association for Clinical Chemistry.