Clinical Chemistry
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Clinical Chemistry 19: 1202-1204, 1973;
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Clinical Chemistry, Vol 19, 1202-1204, Copyright © 1973 by the American Association for Clinical Chemistry

Spurious Elevation of Apparent Lactate Dehydrogenase Activity Caused by Triamterene

T. Chainuvati 1, U. Harinasuta 1, and H. J. Zimmerman 1

1 Medical Service, Veterans Administration Hospital and the Department of Medicine, George Washington University School of Medicine, Washington, D. C. 20422.

Triamterene induced spurious elevations in serum lactate dehydrogenase activity, as assayed by an automated fluorometric method; the enzyme activities were normal when measured spectrophotometrically. Solutions of the drug in normal serum or physiological saline, without addition of substrate or coenzyme, yielded high values for apparent "enzyme" activity by the fluorometric assay.

Submitted on July 19, 1971
Accepted on July 31, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.