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Clinical Chemistry 19: 1374-1379, 1973;
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Clinical Chemistry, Vol 19, 1374-1379, Copyright © 1973 by the American Association for Clinical Chemistry

Factors Contributing to Intra-Individual Variation of Serum Constituents: 1. Within-Day Variation of Serum Constituents in Healthy Subjects

Bernard E. Statland 1, Per Winkel 1, and Henning Bokelund 1

1 Department of Clinical Chemistry A, Rigshospitalet, State University Hospital, Copenhagen, Denmark (B. E. S. and P. W.); and the Department of Clinical Chemistry, Odense University Hospital, Odense, Denmark (H. B.).

Bernard E. Statland, M.D., Ph.D., Department of Laboratory Medicine, University of Minnesota Hospital, Minneapolis, Minn. 55455.

We evaluated the within-day variation of serum constituents in a group of 11 healthy young men. Twenty-two constituents were assayed at the same time, 19 of them on the " AutoChemist" multi-channel analyzer. The statistical model of analysis-of-variance was used to separate certain factors—subject, time of day, and subject-time interaction— from the analytical variation. The estimate of analytical variation was based on data for duplicate samples of blood which were taken from all subjects at 0800 h, 1100 h, and 1400 h. The following serum constituents varied significantly (P <0.05) as a function of time of day: sodium, potassium, chloride, urea, iron, bilirubin, total lipids, and acid phosphatase.


Key Words: diurnal variation • circadian rhythms • analysis of variance • individual vs. analytical variation

Submitted on October 8, 1973
Accepted on October 11, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.