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Clinical Chemistry 19: 1380-1383, 1973;
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Clinical Chemistry, Vol 19, 1380-1383, Copyright © 1973 by the American Association for Clinical Chemistry

Factors Contributing to Intra-Individual Variation of Serum Constituents: 2. Effects of Exercise and Diet on Variation of Serum Constituents in Healthy Subjects

Bernard E. Statland 1, Per Winkel 1, and Henning Bokelund 1

1 Department of Clinical Chemistry A, Rigshospitalet, State University Hospital, Copenhagen, Denmark (B. E. S. and P. W.); and the Department of Clinical Chemistry, Odense University Hospital, Odense, Denmark (H. B.).

Bernard E. Statland, M.D., Ph.D., Department of Laboratory Medicine, University of Minnesota Hospital, Minneapolis, Minn. 55455.

A previous report of within-day variation of serum constituents was based on values in healthy subjects who did not undergo strenuous exercise and who were in a fasting state. In this study we consider the effects of exercise and of a noon meal on the same serum constituents. The statistical significance (t-test) was computed on the basis of the ratios of values (after/before) on the day of exercise vs. the ratios on the nonexercise day, or, for the effect of meal, the ratios of values (after/before the noon meal) on the eating day vs. the ratios of values taken at the same hour on the fasting day. Significant effects seen after exercise (P <.05) included: potassium, phosphate, creatinine, total protein, albumin, uric acid, and alanine aminotransferase. After the noon meal, significant (P <.05) changes were seen for: sodium, phosphate, uric acid, iron, total lipids, alkaline phosphatase (phenyl phosphate substrate), and lactate dehydrogenase. The effects of eating on serum constituents are separated into (a) physiological factors and (b) methodological considerations.

Submitted on October 8, 1973
Accepted on October 11, 1973




The following articles in journals at HighWire Press have cited this article:


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[Abstract] [Full Text] [PDF]


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Copyright © 1973 by the American Association for Clinical Chemistry.