Clinical Chemistry
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Clinical Chemistry 19: 1396-1399, 1973;
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Clinical Chemistry, Vol 19, 1396-1399, Copyright © 1973 by the American Association for Clinical Chemistry

Plasma Renin Activity: A Method for Rapid Screening by Radioimmunoassay and a Comparison of Two Commercially Available Kits

Samuel D. Goldberg 1 and F. W. Spierto 1

1 Center for Disease Control, U. S. Department of HEW, Atlanta, Ga. 30333.

Twenty to thirty percent of patients with essential hypertension have subnormal plasma renin activity (PRA) and lower incidences of stroke and myocardial infarction. NaCl intake influences PRA, which should thus be compared with 24-h urinary sodium excretion. Because such specimens are difficult to collect accurately, we investigated the relation between PRA and sodium in casual (i.e., untimed) urine specimens and found none. However, PRA and urinary Na/creatinine ratio are inversely correlated for casual specimens. This method is useful for screening individuals whose salt intake is low. Mean PRA, measured by the Schwarz-Mann procedure, was 0.62 ± 0.12 (SD) ng/ml per hour for 59 normotensive volunteers, 35% lower by the Squibb procedure.


Key Words: essential hypertension • PRA and salt intake • normal range

Submitted on August 7, 1973
Accepted on October 5, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.