Clinical Chemistry
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Clinical Chemistry 19: 261-263, 1973;
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Clinical Chemistry, Vol 19, 261-263, Copyright © 1973 by the American Association for Clinical Chemistry

Additional Observations on Hydrochlorothiazide Interference with Measurement of Total Urinary Placental Estrogens

A. Arnaldo Acosta 1, Linda B. Madeira 1, Paige K. Besch 1, and Veasy C. Buttram Jr. 1

1 Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Tex. 77025; and St. Luke’s Episcopal Hospital, Houston, Tex. 77025.

The diuretic, hydrochlorothiazide, which enjoys widespread clinical use, decreases the apparent assay values for total urinary estrogens by directly interfering with formation of the Kober chromogen. Urine from patients receiving this medication may give a falsely low total estrogen value. Chlorothiazide, a closely related diuretic, does not so interfere.


Key Words: Kober reaction for estrogens, interference with • diagnostic aid

Accepted on October 10, 1972






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Copyright © 1973 by the American Association for Clinical Chemistry.