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Clinical Chemistry 19: 301-303, 1973;
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Clinical Chemistry, Vol 19, 301-303, Copyright © 1973 by the American Association for Clinical Chemistry

Automated Fluorometric Method for Screening for Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency

Larry G. Dickson 1, Carl B. Johnson 1, and Donald R. Johnson 1

1 Experimental Pathology Division, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Md. 20014, and the Bureau of Medicine and Surgery, Navy Department, Research Task No. MRO41.20.01-0326A2GX.

Deficiency of the erythrocyte enzyme, glucose-6-phosphate dehydrogenase [EC 1.1.1.49, GPD] is associated with hemolysis after exposure to oxidative drugs, ingestion of the fava bean, or infection. Episodes of hemolysis may be prevented by avoiding ingestion of substances toxic to erythrocytes with GPD deficiency. We describe here an automated fluorometric method suitable for screening for erythrocyte GPD deficiency. Anticoagulated whole blood is examined. Reliable results are obtained for hemoglobin concentrations ranging from 7-17 g/100 ml.


Key Words: hemolytic anemia • AutoAnalyzer • manual spot-test method compared

Submitted on October 25, 1972
Accepted on December 11, 1972






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Copyright © 1973 by the American Association for Clinical Chemistry.