Clinical Chemistry
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Clinical Chemistry 19: 366-372, 1973;
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Clinical Chemistry, Vol 19, 366-372, Copyright © 1973 by the American Association for Clinical Chemistry

The Usefulness of Laboratory Tests in Health-Screening Programs

David L. Sackett

I discuss pitfalls in laboratory-screening programs: regression toward the mean on repeated biochemical determinations; the problem of defining normalcy in the interpretation of laboratory test results; and a remarkable professional myopia in which clinical chemists have, with rare exception, failed to accept responsibility for evaluating whether the programs in which they are engaged are of benefit to patients.


Key Words: assessment of multiphasic testing • normal ranges • regression toward the mean • applicability of standard deviation • clinical interpretation of laboratory results

Accepted on January 10, 1973




The following articles in journals at HighWire Press have cited this article:


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R. D. CEBUL and J. R. BECK
Diagnostic Decision: Biochemical Profiles * Applications in Ambulatory Screening and Preadmission Testing of Adults
Ann Intern Med, March 1, 1987; 106(3): 403 - 413.
[Abstract] [PDF]

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C. C. KORVIN, R. H. PEARCE, and J. STANLEY
Admissions Screening: Clinical Benefits
Ann Intern Med, August 1, 1975; 83(2): 197 - 203.
[Abstract] [PDF]

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J. C. BOYD and J. J. MARR
Decreasing Reliability of Acid-Fast Smear Techniques for Detection of Tuberculosis
Ann Intern Med, April 1, 1975; 82(4): 489 - 492.
[Abstract] [PDF]


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Copyright © 1973 by the American Association for Clinical Chemistry.