Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 19: 395-402, 1973;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldberg, D. M.
Right arrow Articles by Winfield, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldberg, D. M.
Right arrow Articles by Winfield, D. A.

Clinical Chemistry, Vol 19, 395-402, Copyright © 1973 by the American Association for Clinical Chemistry

Influence of Demographic Factors on Serum Concentrations of Seven Chemical Constituents in Healthy Human Subjects

David M. Goldberg 1, Alan J. Handyside 1, and David A. Winfield 1

1 Department of Chemical Pathology, Royal Hospital, Sheffield; and the Department of Community Medicine, The University, Sheffield, U. K.

Serum from 519 subjects attending a screening clinic and from the laboratory staff was used to study the influence of age, sex, body weight, social class, blood pressure, and smoking habit upon the concentration in serum of urea, uric acid, cholesterol, inorganic phosphate, total protein, calcium, and magnesium. Values for urea, uric acid, calcium, and magnesium were significantly higher in males. Age was a positive determinant of urea and cholesterol in both sexes, and of magnesium in females only. The correlation of uric acid with age was positive in females and negative in males, but in both sexes the correlation between uric acid and weight was strongly positive. Regression equations were developed to express the demographic and nondemographic contributions to the individual's blood chemistry values. From these, a set of demographically-corrected reference values were derived. When applied to a selected group of female hospital outpatients, these seemed to discriminate more accurately between subjects with and without disease than did conventional parametric limits.


Key Words: influence of age, sex, weight, social class, blood pressure, and smoking on serum urea, uric acid, cholesterol, Pi, total protein, calcium, magnesium

Accepted on January 5, 1973






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 by the American Association for Clinical Chemistry.