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Clinical Chemistry 19: 408-410, 1973;
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Clinical Chemistry, Vol 19, 408-410, Copyright © 1973 by the American Association for Clinical Chemistry

Improved Method for Specific Determination of Creatinine in Serum and Urine

Robert J. Mitchell 1

1 Ames Co., Division of Miles Laboratories, 1127 Myrtle St., Elkhart, Ind. 46514.

A simple method has been developed for measuring creatinine in serum and urine. Small, fast-flowing cation-exchange columns are used to separate creatinine from interfering substances. The creatinine is eluted and determined with the Jaffe reaction. The results agree well with those for the procedure in which Lloyd's reagent is used.


Key Words: creatinine clearance • interference removed by use of cation-exchange columns • Lloyd's reagent method compared

Submitted on October 25, 1972
Accepted on January 29, 1973




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Copyright © 1973 by the American Association for Clinical Chemistry.