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Clinical Chemistry, Vol 19, 429-430, Copyright © 1973 by the American Association for Clinical Chemistry
1 Department of Laboratory Medicine, University of
Connecticut School of Medicine, Farmington, Conn. 06032.
Nickel was measured by atomic absorption spectrometry in three-day collections of feces from
healthy hospital workers (age 22-65) who had lived
for more than a year in Hartford, Connecticut. None
of the 10 subjects (4/
, 6/
.) had occupational exposure to nickel. Fecal nickel averaged 3.3 µg/g
(wet weight); SD, ±0.8; and range, 2.1 to 4.4 µg/g.
Corresponding figures on a dry-weight basis were
14.2 µg/g; SD, ±2.7; and range, 10.8 to 18.7 µg/g.
The fecal excretion of nickel averaged 258 µg/day
(SD, ±126; range, 80 to 540 µg/day). Fecal excretion is evidently the major route for elimination of
nickel from the human body. Comprehensive evaluations of environmental or occupational exposures to
nickel should also include analyses of nickel in serum,
urine, and hair.
Submitted on December 8, 1972
Accepted on January 5, 1973
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