Clinical Chemistry
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Clinical Chemistry 19: 492-495, 1973;
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Clinical Chemistry, Vol 19, 492-495, Copyright © 1973 by the American Association for Clinical Chemistry

Rapid Method for Quantitative Determination of Propoxyphene in Serum by Gas-Liquid Chromatography

M. A. Evenson 1 and Susan Koellner 1

1 Department of Medicine and the Clinical Chemistry Laboratory, University of Wisconsin Hospitals, Madison, Wis. 53706.

Rapid, accurate, and precise gas-chromatographic methods are reported for measurement of propoxyphene ("Darvon") in serum. A sample of 5 ml of serum is required for quantitation in blood after a therapeutic dose of 130-195 mg of propoxyphene; in cases of overdose of propoxyphene, only 1 ml of serum is required in a "toxic method" variation. Neither serum from healthy controls or from hospitalized patients contains interfering substances. Several commonly used analgesic and sedative drugs, added to a serum pool, also did not interfere. Day-to-day precision of the therapeutic method, as measured by the coefficient of variation (CV), is 7%; the CV for the method as applied to overdose cases is less than 3%. Propoxyphene added to serum could be about 86% accounted for analytically.


Key Words: drugs of abuse • drug analysis • accuracy • precision • interferences • internal standard • toxicology

Submitted on December 8, 1972
Accepted on March 1, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.