Clinical Chemistry
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Clinical Chemistry 19: 531-532, 1973;
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Clinical Chemistry, Vol 19, 531-532, Copyright © 1973 by the American Association for Clinical Chemistry

Formaldehyde Interference in the Uric Acid—Phosphotungstic Acid Redox

Bernard Klein 1 and Joan Sheehan 1

1 Department of Diagnostic Research, Hoffmann-La Roche Inc., Nutley, N.J. 07110.

Formaldehyde, in quantities used to preserve uric acid standard solutions, will introduce errors in the automated analysis of serum uric acid by the Technicon N-13b phosphotungstate procedure, by retarding the dialysis rate. It will also diminish recovery of uric acid when these solutions are added to serum. The mechanism of interference is complex and may involve alteration of dialysis rates, formaldehyde— protein—uric acid interaction, and possibly a competing redox with phosphotungstic acid.


Key Words: AutoAnalyzer • retardation of dialysis

Submitted on February 1, 1973
Accepted on March 5, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.