Clinical Chemistry
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Clinical Chemistry 19: 533-535, 1973;
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Clinical Chemistry, Vol 19, 533-535, Copyright © 1973 by the American Association for Clinical Chemistry

Comparison of Results for Three Methods of Hemoglobin S Identification

Edward J. Hicks 1, John A. Griep 1, and Carleton D. Nordschow 1

1 Department of Clinical Pathology, Indiana University Medical Center, Indianapolis, Ind. 46202.

We present comparative results of three diagnostic tests for identification of hemoglobin S, performed on specimens from a total of 4,739 persons. A simple, rapid, and economical procedure for cellulose acetate electrophoresis was more efficient than either the "Sickledex" test (a dithionite test) or the metabisulfite reduction test. This is an important consideration as a minimum requirement for effective therapy and genetic counseling. We propose electrophoresis of hemoglobin on cellulose acetate as a primary screening procedure—with verification of positive samples by solubility tests—and discuss its feasibility.


Key Words: hemoglobin phenotypes • sickle cell anemia • mass screening • "Sickledex" and metabisulfite tests compared with electrophoresis

Submitted on February 9, 1973
Accepted on March 9, 1973




The following articles in journals at HighWire Press have cited this article:


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R. M. Nalbandian, F. R. Camp Jr, R. L. Henry, and N. F. Conte
Mass Screening for Sickle Cell Hemoglobin: Is There an Optimal Method?
JAMA, November 24, 1975; 234(8): 832 - 835.
[Abstract] [PDF]


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Copyright © 1973 by the American Association for Clinical Chemistry.