Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 19: 583-585, 1973;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stein, I. M.
Right arrow Articles by Micklus, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stein, I. M.
Right arrow Articles by Micklus, M. J.

Clinical Chemistry, Vol 19, 583-585, Copyright © 1973 by the American Association for Clinical Chemistry

Concentrations in Serum and Urinary Excretion of Guanidine, 1-Methylguanidine, and 1,1-Dimethylguanidine in Chronic Renal Failure

Israel M. Stein 1 and Michael J. Micklus 1

1 Departments of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Mass. 02215.

Guanidine (G), 1-methylguanidine (MG), and 1,1-dimethylguanidine (DMG) have long been implicated as uremic "toxins." A method has been developed for determining G, MG, and DMG in serum and urine. Specimens were chromatographed on carboxylate resin, with use of 1 molar NaOH, and quantitated colorimetrically with a modification of the Voges— Proskauer reaction. The mean values for G and MG in the serum of uremic patients were 0.3 and 0.4 mg per liter, respectively. DMG was not detected. Although the urinary excretion of MG is significantly increased in renal failure, the concentrations of G, MG, and DMG in serum are not markedly increased, and it is therefore unlikely that G, MG, or DMG contribute to the toxic manifestations of the uremic syndrome.


Key Words: "toxins" in uremia • ion-exchange column-chromatography • Voges—Proskauer reaction • uremic syndrome

Submitted on February 21, 1973
Accepted on March 16, 1973






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 by the American Association for Clinical Chemistry.