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Clinical Chemistry 19: 590-592, 1973;
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Clinical Chemistry, Vol 19, 590-592, Copyright © 1973 by the American Association for Clinical Chemistry

Simultaneous Determination of Carbamazepine ("Tegretol") and Other Anticonvulsants in Human Plasma by Gas—Liquid Chromatography

Jean-Claude Roger 1, George Rodgers Jr. 1, and Alex Soo 1

1 Ciba-Geigy Corporation, the Pharmaceuticals Division, Ardsley, N. Y. 10502.

A gas chromatographic method in which an on-column reaction with a methylating reagent is used has been developed that permits the simultaneous determination of plasma concentrations of carbamazepine and of some other commonly co-administered anticonvulsant drugs, including phenobarbital, diphenylhydantoin, primidone, and mephenytoin. As little as 0.5 µg of any of these drugs can be determined per milliliter of plasma.

Accepted on March 30, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.