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Clinical Chemistry 19: 611-614, 1973;
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Clinical Chemistry, Vol 19, 611-614, Copyright © 1973 by the American Association for Clinical Chemistry

Modified Pisano Method for Estimating Urinary Metanephrines

R. N. Gupta 1, D. Price 1, and P. M. Keane 1

1 Department of Laboratory Medicine, St. Joseph’s Hospital; and the Department of Pathology, McMaster University, Hamilton, Ontario.

The Pisano method [Clin. Chim. Acta 5, 406 (1960)] for estimating urinary metanephrine, used in the screening of hypertensive persons for pheochromocytoma, has been modified by replacing ion-exchange chromatography with differential solvent extraction. An internal standard is incorporated to correct for procedural losses. Interference from some related compounds is negligible. Normal-range values obtained for various age groups by the present method compare well with those obtained by Pisano’s procedure, but are higher than values reported for more specific methods.


Key Words: diagnosis of pheochromocytoma, neuroblastoma • differential solvent extraction procedure • normal values • neural crest tumors • screening procedure

Submitted on January 15, 1973
Accepted on April 6, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.