Clinical Chemistry
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Clinical Chemistry 19: 1036-1039, 1973;
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Clinical Chemistry, Vol 19, 1036-1039, Copyright © 1973 by the American Association for Clinical Chemistry

Application of an Automated Determination of Isoenzyme-5 of Lactate Dehydrogenase to the Diagnosis of Hepatic Disease

Lawrence E. Nathan Jr. 1, Donald Feldbruegge 1, and James O. Westgard 1

1 Departments of Pathology and Medicine, University of Wisconsin, Milwaukee, Wis., March 27, 1973.

We have examined the clinical usefulness of measuring the activity of LD-5 (the slowest-moving isoenzyme of lactate dehydrogenase) in serum, after its column chromatographic separation, on the Du Pont ACA. Primary and secondary diseases of the liver were readily identified. LD-5 and alanine aminotransferase activities correlated well in hepatitis and LD-5 and alkaline phosphatase activities in metastatic disease of the liver. LD-5 activity was elevated in cases of congestive heart failure, muscle trauma, and cirrhosis (when associated with active inflammation or alcoholic hepatitis). The test proved most useful for the early identification of hepatitis and tumor involvement of the liver.


Key Words: isoenzymes • Du Pont ACA • diagnosis of hepatitis, hepatic tumor • activities of other enzymes compared to LD • normal values

Submitted on May 11, 1973
Accepted on June 22, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.