Clinical Chemistry
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Clinical Chemistry 19: 943-949, 1973;
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Clinical Chemistry, Vol 19, 943-949, Copyright © 1973 by the American Association for Clinical Chemistry

Effects of Lysine on Ammonia Formation, Hydrogen Ion, and Potassium Ion Balance: A Review and an Hypothesis

Jack I. Zweig 1

1 Department of Medicine, Beth Israel Medical Center, New York, N.Y. 10003.

Evidence is assembled that lysine acts as an intracellular hydrogen ion acceptor, causing increased ammonia formation and increased potassium excretion in certain disease states. It is suggested that other intracellular dibasic amino acids may have the same effects.


Key Words: arginine, ornithine • acid-base balance • urea formation • ammonia formation • intracellular K+ and H+

Submitted on March 6, 1973
Accepted on June 2, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.