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Clinical Chemistry 20: 19-21, 1974;
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Clinical Chemistry, Vol 20, 19-21, Copyright © 1974 by the American Association for Clinical Chemistry

Activation of the Kinin-Forming System during Therapy with Cyclophosphamide

A. Cuschieri 1

1 Department of Surgery, University of Liverpool, P. O. Box 147, Liverpool, L69 3BX, U. K.

Venous blood kininogen is significantly decreased during therapy with cyclophosphamide in cases of advanced breast cancer. The maximum decrease in plasma kininogen coincided with onset of maximal leukopenia in the peripheral venous blood. In vitro studies showed that both human whole blood and mononuclear cell suspensions liberate free kinin when incubated with cyclophosphamide, but plateletfree human plasma does not. Evidently, the kinin-forming system is activated during therapy with cyclophosphamide, and this may account for some of its reported side effects. The in vitro studies suggest that this activation results from damage to peripheral blood leukocytes by the cyclophosphamide, with the release of intracellular proteases.


Key Words: kallikrein • bradykinin • kinin and cancer treatment

Submitted on May 28, 1973
Accepted on October 16, 1973






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Copyright © 1974 by the American Association for Clinical Chemistry.