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Clinical Chemistry 20: 26-29, 1974;
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Clinical Chemistry, Vol 20, 26-29, Copyright © 1974 by the American Association for Clinical Chemistry

Nature of Isoamylases Released, by Acidification, from Macroamylase Complexes

L. Fridhandler 1, J. Edward Berk 1, and K. Montgomery 1

1 Department of Medicine, California College of Medicine, University of California, Irvine, 101 City Drive South, Orange, Calif. 92668.

We describe observations of the isoamylase nature of the amylase released by acid from partially purified macroamylase complexes that are dissociable under acid conditions. The released isoamylases displayed the chromatographic characteristics previously found in the pancreatic type (P-type) and salivary type (S-type) of amylases in human serum and urine. The proportions of S- and P-types released from 30 macroamylase complexes varied over a much wider range than those proportions found in 27 normal sera. Of particular note was the relatively large number of cases in which there was a marked preponderance of S-type in the released amylase. These data testify further to the varied nature of cases of macroamylasemia, and contribute additionally to their systematic classification.


Key Words: hyperamylasemia • macroamylasemia • pancreatic and salivary amylases • etiology and classification of amylasemia • Sephadex chromatography

Accepted on October 16, 1973






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Copyright © 1974 by the American Association for Clinical Chemistry.