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Clinical Chemistry 20: 83-84, 1974;
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Clinical Chemistry, Vol 20, 83-84, Copyright © 1974 by the American Association for Clinical Chemistry

Relative Affinity of Hemoglobin S and Hemoglobin A for Carbon Monoxide and Oxygen

F. Lee Rodkey 1, John D. O'Neal 1, Harold A. Collison 1, and David E. Uddin 1

1 Laboratory of Analytical Biochemistry and the Experimental Medicine Division, U. S. Naval Medical Research Institute, National Naval Medical Center, Bethesda, Md. 20014.

The relative affinity constants of hemolysates from individuals with hemoglobins A, S, or AS have been measured at 37 and 26 ° C. Observed values of all hemoglobin types were the same at both temperatures, K37 = 230, K26 = 296. Control measurements on whole blood containing Hb A gave values of K37 = 222. The small but significant difference between K37 values measured in whole blood and in hemolysates may be a result of the greater increase of MetHb in the hemolysates during the in vitro equilibration.


Key Words: Haldane constant • carboxyhemoglobin • sickle cell disease • electrophoresis on cellulose acetate • gas chromatography

Submitted on October 25, 1973
Accepted on November 9, 1973




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