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Clinical Chemistry, Vol 20, 1344-1348, Copyright © 1974 by the American Association for Clinical Chemistry
1 Institute of Health Research, P.O. Box 7999, San Francisco,
Calif. 94120.
A chemical test to distinguish smokers and nonsmokers is important in many epidemiologic studies. We have developed an automated method for determining serum thiocyanate by use of the reaction between thiocyanate and ferric ions to form a colored complex. Our data show that this method distinguishes cigarette smokers and nonsmokers: of 197 healthy individuals studied, 1.8% false-positive and 6.7% false-negative results were obtained when 85 µmol of SCN- per liter was the critical value used to distinguish the two populations.
Submitted on June 24, 1974
Accepted on August 6, 1974
The following articles in journals at HighWire Press have cited this article:
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  P. Laurberg, S. B. Nohr, K. M. Pedersen, and E. Fuglsang Iodine Nutrition in Breast-Fed Infants Is Impaired by Maternal Smoking J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 181 - 187. [Abstract] [Full Text] [PDF]
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L. M. Galanti Specificity of Salivary Thiocyanate as Marker of Cigarette Smoking Is Not Affected by Alimentary Sources Clin. Chem., January 1, 1997; 43(1): 184 - 185. [Full Text]
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 P. G. McGovern, J. S. Pankow, E. Shahar, K. M. Doliszny, A. R. Folsom, H. Blackburn, R. V. Luepker, and The Minnesota Heart Survey Investigators Recent Trends in Acute Coronary Heart Disease -- Mortality, Morbidity, Medical Care, and Risk Factors N. Engl. J. Med., April 4, 1996; 334(14): 884 - 890. [Abstract] [Full Text] [PDF]
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 A. C. King, C. B. Taylor, and W. L. Haskell Smoking in Older Women: Is Being Female a 'Risk Factor' for Continued Cigarette Use? Arch Intern Med, September 1, 1990; 150(9): 1841 - 1846. [Abstract] [PDF]
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 C. B. Taylor, N. Houston-Miller, J. D. Killen, and R. F. DeBusk Smoking Cessation after Acute Myocardial Infarction: Effects of a Nurse-Managed Intervention Ann Intern Med, July 15, 1990; 113(2): 118 - 123. [Abstract] [PDF]
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S. P. Fortmann, J. D. Killen, M. J. Telch, and B. Newman Minimal Contact Treatment for Smoking Cessation: A Placebo Controlled Trial of Nicotine Polacrilex and Self-directed Relapse Prevention: Initial Results of the Stanford Stop Smoking Project JAMA, September 16, 1988; 260(11): 1575 - 1580. [Abstract] [PDF]
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 G.K. Stookey, B.P. Katz, B.L. Olson, C.A. Drook, and S.J. Cohen Evaluation of Biochemical Validation Measures in Determination of Smoking Status Journal of Dental Research, October 1, 1987; 66(10): 1597 - 1601. [Abstract] [PDF]
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T. F. Pechacek, A. R. Folsom, R. de Gaudermaris, D. R. Jacobs Jr, R. V. Luepker, R. F. Gillum, and H. Blackburn Smoke Exposure in Pipe and Cigar Smokers: Serum Thiocyanate Measures JAMA, December 20, 1985; 254(23): 3330 - 3332. [Abstract] [PDF]
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R. H. Grimm Jr, J. D. Neaton, W. Ludwig, and Multiple Risk Factor Intervention Trial Research G Prognostic Importance of the White Blood Cell Count for Coronary, Cancer, and All-Cause Mortality JAMA, October 11, 1985; 254(14): 1932 - 1937. [Abstract] [PDF]
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D. W. Sepkovic, N. J. Haley, and E. L. Wynder Thyroid Activity in Cigarette Smokers Arch Intern Med, March 1, 1984; 144(3): 501 - 503. [Abstract] [PDF]
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M. Sexton and J. R. Hebel A Clinical Trial of Change in Maternal Smoking and Its Effect on Birth Weight JAMA, February 17, 1984; 251(7): 911 - 915. [Abstract] [PDF]
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Multiple Risk Factor Intervention Trial Research G Multiple Risk Factor Intervention Trial: Risk Factor Changes and Mortality Results JAMA, September 24, 1982; 248(12): 1465 - 1477. [Abstract] [PDF]
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