Clinical Chemistry
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Clinical Chemistry 20: 1438-1440, 1974;
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Clinical Chemistry, Vol 20, 1438-1440, Copyright © 1974 by the American Association for Clinical Chemistry

The Hoesch Test: Bedside Screening for Urinary Porphobilinogen in Patients with Suspected Porphyria

Joel Lamon 1, Torben K. With 1, and Allan G. Redeker 1

1 Department of Internal Medicine, University of Southern California School of Medicine, Los Angeles, Calif. 90033; and the Department of Chemical Pathology, Svendborg Hospital, 5700 Svendborg, Denmark.

A little-known procedure for porphobilinogen screening, the Hoesch test, was examined for sensitivity, specificity, and utility as compared to the Watson-Schwartz test. The data demonstrate that its sensitivity is similar to that of the Watson-Schwartz test. The Hoesch test, however, is without false-positive reactions secondary to urobilinogen, and its simplicity makes it easier to use and more easily interpretable. We conclude that the Hoesch test should replace the Watson-Schwartz test for urine porphobilinogen screening in suspected cases of acute intermittent and variegate porphyria.


Key Words: Watson-Schwartz • "reversed Ehrlich reaction" • screening

Submitted on June 28, 1974
Accepted on August 26, 1974




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J. M. Lamon, B. C. Frykholm, and D. P. Tschudy
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