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Clinical Chemistry 20: 1460-1462, 1974;
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Clinical Chemistry, Vol 20, 1460-1462, Copyright © 1974 by the American Association for Clinical Chemistry

Rapid Gas-Chromatographic Determination of Amphetamine and Methamphetamine in Urine

Naresh C. Jain 1, Thomas C. Sneath 2, and Robert D. Budd 2

1 Departments of Pharmacology, and of Community Medicine and Public Health, University of Southern California School of Medicine, Los Angeles, Calif. 90033.Rancho Los Amigos Hospital, 7601 E. Imperial Highway, Downey, Calif. 90242
2 Rancho Los Amigos Hospital, 7601 E. Imperial Highway, Downey, Calif. 90242

A simple, rapid procedure is described for measuring amphetamine and methamphetamine in urine by gas chromatography, with use of a flame ionization detector. This method is sensitive to subtherapeutic concentrations (0.1 µg/ml or less), and is especially useful in clinical situations where an accurate and quantitative result is needed in less than 30 min. With the method, amphetamine and methamphetamine can be determined as the free bases on a 10% Apiezon L-10% KOH column and as their trifluoroacetamide derivatives on a 3% OV-17 column. This dual analysis eliminates false positives and any interfering substances that may be present in the urine, and is thus a specific method for the two drugs.

Submitted on May 3, 1974
Accepted on August 26, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.