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Clinical Chemistry 20: 172-176, 1974;
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Clinical Chemistry, Vol 20, 172-176, Copyright © 1974 by the American Association for Clinical Chemistry

Drug-Abuse and Control Populations Differentiated by a Laboratory Profile

Lewis W. Mayron 1, Ervin Kaplan 1, Stearly Alling 1, and Jack Becktel 1

1 GM&S Research Service, Nuclear Medicine Service, Psychiatry Service and Hines VA Cooperative Studies Program Support Center, Veterans Administration Hospital, Hines, Ill. 60141.

By multivariate analysis of nine laboratory variables, a discriminant function value has been derived that differentiated between a group of 106 drug abusers and a group of 100 normal controls. The variables were serum phosphorus, glucose, lactate dehydrogenase, aspartate aminotransferase, and hematocrit, total leukocyte count, polymorphonuclear leukocyte count, lymphocyte count, and monocyte count. The data demonstrate that the two populations can be distinguished with 4% error in the control group and 14% error in the drug-abuse group. In addition, the individual variables for each group were compared by the t-test. The following were significantly different: serum calcium, phosphorus, blood urea nitrogen, cholesterol, albumin, total bilirubin, alkaline phosphatase, aspartate aminotransferase, and hemoglobin, hematocrit, leukocyte count, polymorphonuclear leukocyte count, stab cell count, and eosinophil count.


Key Words: multivariate analysis • statistics • variation, source of • screening

Submitted on May 25, 1973
Accepted on November 5, 1973






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Copyright © 1974 by the American Association for Clinical Chemistry.