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Clinical Chemistry 20: 230-235, 1974;
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Clinical Chemistry, Vol 20, 230-235, Copyright © 1974 by the American Association for Clinical Chemistry

Identification of Free and Conjugated Metabolites of Methaqualone by Gas Chromatography—Mass Spectrometry

R. Bonnichsen 1, V. Mårde 1, and R. Ryhage 1

1 Government Laboratory for Forensic Chemistry, and Laboratory for Mass Spectrometry, Karolinska Institute, Stockholm, Sweden.

Gas chromatography—mass spectrometry was used to identify and measure methaqualone metabolites. All samples were silylated before analysis. Free and conjugated metabolites of methaqualone in urine, liver, and blood were studied in three suicide cases. Both free and conjugated metabolites were found in blood and urine, only free metabolites in liver. The conjugated metabolites were hydrolyzed with hydrochloric acid. A comparison hydrolysis with beta-glucuronidase showed that much of the sample was destroyed by hydrolysis with hydrochloric acid. Mass chromatography is presented as a computer-based gas chromatographic—mass spectrometric method.


Key Words: drug abuse • methaqualone metabolites • toxicology • computer • drug metabolism

Submitted on October 26, 1973
Accepted on November 19, 1973






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Copyright © 1974 by the American Association for Clinical Chemistry.