Clinical Chemistry
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Clinical Chemistry 20: 266-271, 1974;
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Clinical Chemistry, Vol 20, 266-271, Copyright © 1974 by the American Association for Clinical Chemistry

Radioimmunoassay for Dexamethasone in Plasma

Martin Hichens 1 and Alice F. Hogans 1

1 Merck Institute for Therapeutic Research, Rahway, N. J. 07065, and the Merck Institute for Therapeutic Research, West Point, Pa. 19486.

We describe a radioimmunoassay for detection of dexamethasone in plasma. Antibodies to dexamethasone hemisuccinate coupled to bovine serum albumin were obtained in rabbits and used for binding of the synthetic steroid. Concentrations of dexamethasone between 0.5 and 40 µg/liter of plasma can be measured with this procedure.


Key Words: new method for preparing hapten —albumin conjugate • drug assay • monitoring of therapy

Submitted on July 6, 1973
Accepted on November 28, 1973




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Copyright © 1974 by the American Association for Clinical Chemistry.